Associate Director/Sr Research Investigator/Research Investigator, QSP & PBPK Methods
Company: Disability Solutions
Location: Princeton
Posted on: April 15, 2024
Job Description:
Working with UsChallenging. Meaningful. Life-changing. Those
aren't words that are usually associated with a job. But working at
Bristol Myers Squibb is anything but usual. Here, uniquely
interesting work happens every day, in every department. From
optimizing a production line to the latest breakthroughs in cell
therapy, this is work that transforms the lives of patients, and
the careers of those who do it. You'll get the chance to grow and
thrive through opportunities uncommon in scale and scope, alongside
high-achieving teams rich in diversity. Take your career farther
than you thought possible.Bristol Myers Squibb recognizes the
importance of balance and flexibility in our work environment. We
offer a wide variety of competitive benefits, services and programs
that provide our employees with the resources to pursue their
goals, both at work and in their personal lives. Read more:
careers.bms.com/working-with-us .Quantitative Systems Pharmacology
(QSP) & Physiologically Based Pharmacokinetics (PBPK) have become
important components of discovery and clinical development.
Mechanistic model and data characterization, calibration, and
validation are critical aspects of QSP&PBPK modeling approaches
needed during model development and application to establish
confidence in models, confidence in their predictions, and leverage
data to guide modeling efforts in impactful ways. Our QSP&PBPK
team has established expertise, impact, and tools to develop,
calibrate, and apply QSP and PBPK models. We are searching for a
scientist with expertise in model calibration algorithms and
pipelines and strong coding experience to guide the team's
methodology and technology strategies, as well as future
innovation. Expertise with virtual population approaches is highly
desired but advanced mathematical or statistical training and
experience developing customized Bayesian algorithms would be a
reasonable background. This scientist will bring expertise in
modeling and calibrating the population variability, characterizing
uncertainty, and experience leading scripted toolbox and new method
development. Ideally the individual will also have interest in
developing and deploying apps and tools for colleagues of various
backgrounds as well as adapting approaches from machine learning.
The individual will play a critical role unifying the team's
technology strategy, maintaining technology and keeping code
up-to-date, improving and adapting best practices and maintaining
rigor in light of emerging regulatory guidelines for mechanistic
modeling, mentoring modelers on the methods and technology,
optimizing existing and new methods for efficiency to improve
time-to-impact, and help with project deliverables to speed impact
as part of a highly efficient, collaborative team.
Responsibilities:
- Provide leadership for existing model calibration and computing
capabilities and future model, technology, and algorithm innovation
and development
- Advance novel and rigorous methodologies for population
variability calibration, model sensitivity analysis, and prediction
uncertainty characterization
- Advance existing and lead development of new tools that can be
deployed using parallel resources on compute clusters with
thousands of workers to accelerate characterization and calibration
of ordinary differential equation models with substantial compute
times in high dimensional spaces
- Assist therapeutic area expert modelers to accelerate efforts
and ensure timely model development and calibration to impact drug
development programs and coordinate technology development
- Maintain, advance, and coordinate codebases and documentation
for data integration and analysis as well as model simulation,
characterization, and calibration
- Serve as a primary liaison with company Information Technology
and coordinate QSP&PBPK group technology strategy
- Partner with external groups to accelerate the internal efforts
in key technology areas
- Establish standards of practice within the department
- Align QSP&PBPK technology strategy with organizational
priorities
- Network with stakeholders in other functions to facilitate
methods, data, and model development and application
- Serve as a subject matter expert to both internal colleagues
and the external scientific community
- Stay informed with emerging literature and science in the
modeling and simulation sciences
- Build and maintain a personal track record of publication in
the area of QSP & PBPK methods
- Maintain an active relationship with colleagues in Clinical
Pharmacology, Pharmacometrics, & Bioanalysis at the project level
as well as in the advancement of PharmacometricsPosition
requirements:
- Ph.D. in Statistics, Applied Mathematics, Biomedical/Chemical
Engineering, Computer Science, Physics, Computational Biology, or
related field
- M.S. in appropriate field with significantly more experience
may be considered
- Following the Ph.D., 2+ years of mathematical modeling &
computer simulation experience in the pharmaceutical industry for
the Sr. Research Investigator level or 5+ years for the Associate
Director level. No additional industry experience is needed for the
Research Investigator level.
- Experience within the pharmaceutical industry or pharmaceutical
consulting is desired (academic post-doctoral or faculty may be a
consideration depending on the totality of prior experience)
- Excellent understanding of the theory and principles in
optimization and global sensitivity analysis including topics such
as particle swarm optimization, quadratic programming,
variance-based global sensitivity analysis
- Expertise in virtual population methods or related concepts and
strategies for model calibration including applications of
importance sampling and Bayesian algorithmic strategies (Markov
Chain Monte Carlo, Metropolis Hastings, Sequential Monte Carlo,
Likelihood-free methods)
- Experience in modeling pathophysiology and therapies or related
systems biology models with ordinary differential equations
- Track record of developing scripted toolboxes for MATLAB and/or
SimBiology, experience with version control, parallelization
methods, experience profiling and optimizing code, and capability
of quickly learning additional tools as needed such as R and
Julia
- Experience running code on clusters is preferable, including
experience with resources such as MATLAB Parallel Server and/or
workload managers such as SLURM or torque
- Experience working with data integration as well as omics data
sources and methods for their treatment is beneficial
- Ability to learn new areas of quantitative sciences and build
on solid foundation of skills to develop new algorithmic
strategies
- Ability to communicate internally and externally on topics
related to model application and methodologies for QSP & PBPK in
the context of Clinical Pharmacology is required
- Desire to interact as a modeling and simulation expert with
matrix project teams and working closely with experts from
different functional areas (pre-clinical and clinical and multiple
therapeutic areas)For California or MA based role, the following
applies:Research Investigator: the starting compensation for this
job is a range from $97,000 - $135,000, plus incentive cash and
stock opportunities (based on eligibility). Sr. Research
Investigator: the starting compensation for this job is a range
from $121,000 - $167,2000, plus incentive cash and stock
opportunities (based on eligibility). Associate Director: the
starting compensation for this job is a range from $178.000 -
$220,000, plus incentive cash and stock opportunities (based on
eligibility). The starting pay rate takes into account
characteristics of the job, such as required skills and where the
job is performed.Final, individual compensation will be decided
based on demonstrated experience. Eligibility for specific benefits
listed on our careers site may vary based on the job and location.
For more on benefits, please visit our BMS Career Site. Benefit
offerings are subject to the terms and conditions of the applicable
plans then in effect and may include the following: Medical,
pharmacy, dental and vision care. Wellbeing support such as the BMS
Living Life Better program and employee assistance programs (EAP).
Financial well-being resources and a 401(K). Financial protection
benefits such as short- and long-term disability, life insurance,
supplemental health insurance, business travel protection and
survivor support. Work-life programs include paid national holidays
and optional holidays, Global Shutdown days between Christmas and
New Year's holiday, up to 120 hours of paid vacation, up to two (2)
paid days to volunteer, sick time off, and summer hours
flexibility. Parental, caregiver, bereavement, and military leave.
Family care services such as adoption and surrogacy reimbursement,
fertility/infertility benefits, support for traveling mothers, and
child, elder and pet care resources. Other perks like tuition
reimbursement and a recognition program.#LI-OnsiteIf you come
across a role that intrigues you but doesn't perfectly line up with
your resume, we encourage you to apply anyway. You could be one
step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing CareersWith a single
vision as inspiring as Transforming patients' lives through
science--- , every BMS employee plays an integral role in work that
goes far beyond ordinary. Each of us is empowered to apply our
individual talents and unique perspectives in an inclusive culture,
promoting diversity in clinical trials, while our shared values of
passion, innovation, urgency, accountability, inclusion and
integrity bring out the highest potential of each of our
colleagues.On-site Protocol BMS has a diverse occupancy structure
that determines where an employee is required to conduct their
work. This structure includes site-essential, site-by-design,
field-based and remote-by-design jobs. The occupancy type that you
are assigned is determined by the nature and responsibilities of
your role: Site-essential roles require 100% of shifts onsite at
your assigned facility. Site-by-design roles may be eligible for a
hybrid work model with at least 50% onsite at your assigned
facility. For these roles, onsite presence is considered an
essential job function and is critical to collaboration,
innovation, productivity, and a positive Company culture. For
field-based and remote-by-design roles the ability to physically
travel to visit customers, patients or business partners and to
attend meetings on behalf of BMS as directed is an essential job
function. BMS is dedicated to ensuring that people with
disabilities can excel through a transparent recruitment process,
reasonable workplace accommodations/adjustments and ongoing support
in their roles. Applicants can request a reasonable workplace
accommodation/adjustment prior to accepting a job offer. If you
require reasonable accommodations/adjustments in completing this
application, or in any part of the recruitment process, direct your
inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/
eeo -accessibility to access our complete Equal Employment
Opportunity statement. BMS cares about your well-being and the
well-being of our staff, customers, patients, and communities. As a
result, the Company strongly recommends that all employees be fully
vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest
and conviction records, pursuant to applicable laws in your
area.Any data processed in connection with role applications will
be treated in accordance with applicable data privacy policies and
regulations.
Keywords: Disability Solutions, Trenton , Associate Director/Sr Research Investigator/Research Investigator, QSP & PBPK Methods, Executive , Princeton, New Jersey
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