Senior Associate Scientist, Discovery Immunology

Company: Disability Solutions
Location: Princeton
Posted on: September 1, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .Position: Senior Associate Scientist, Discovery ImmunologyLocation: Princeton, NJAt Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science. In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference. The Immunology and Cardiovascular (ICV) Thematic Research Center (TRC) at BMS is one of the fundamental Research and Early Development (R&ED) units delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on the cutting-edge science of today. We leverage BMS's internal innovation engine that includes industry-leading expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other therapeutic modalities. We work closely with our R&ED colleagues in clinical and non-clinical development, project leadership, translational medicine, and informatics to advance therapies based on a deep understanding of causal human biology. Furthermore, we collaborate across the biopharmaceutical ecosystem to establish partnerships that complement our internal expertise.Position SummaryBristol-Myers Squibb is seeking a highly motivated Senior Associate Scientist to join the Discovery Biology Immunology and In Vivo Pharmacology group at the Immunology and Cardiovascular Thematic Research Center located in Lawrenceville, NJ. The qualified candidate will possess the ability to work across a highly matrixed environment to advance drug discovery programs and will be responsible for developing and executing in vivo and ex vivo strategies using a wide range of animal disease models. The candidate must have hands on expertise in executing rodent models of disease from in vivo dosing and ex vivo disease end point analysis. The focus of this position will be the in vivo and ex vivo evaluation of novel therapeutic agents including large and small molecules that will support these drug discovery efforts; additional responsibilities will include identification and validation of novel disease and target specific biomarkers and development of new pharmacodynamic endpoints and disease models for autoimmune indications. The desired candidate will demonstrate sophisticated scientific thinking and have the enthusiasm and capacity to rise to challenges. A strong work ethic, good judgement and ability to work efficiently in a team setting are key qualities in the successful candidate. The position is a hands-on, laboratory-based role. The candidate is expected to be able to plan, design, develop methodologies and execute experiments according to plans and protocols with appropriate supervision.Key Responsibilities

• Execute inflammatory or autoimmune animal disease models to support in vivo pharmacology and biology studies.
• Perform rodent dosing (PO, IP, IV, SC etc.) and tissue collection for ex vivo analysis.
• Develop, troubleshoot, and execute cellular and immunological assays with primary immune cells or cell lines.
• Perform techniques including sterile cell culture, multiplex ELISA, RNA isolation and RT-qPCR. Isolate mononuclear cells from tissues and phenotype cells and cellular responses using multicolor flow cytometry.
• Design and execute well-controlled experiments, perform data analysis, and summarize findings to the team.
• Collaborate alongside a cross-functional team with experts in immunology and in vivo pharmacology to derive new biological mechanistic insights and pharmacodynamic / efficacy assessments, and support programs as they move through pre-clinical development.
• Excellent communication, presentation, collaboration, and organizational skills are required.
• Travel will be less than 5% of the time.Basic Qualifications:
  • Bachelor's Degree
    • 4+ years of academic and / or industry experienceOr
      • Master's Degree
        • 2+ years of academic and / or industry experiencePreferred Qualifications & Experience
          • Bachelor's degree in immunology, biology, biochemistry or biological science with 4+ years or Master's degree with 2+ years of relevant industry / academic experience.
          • Research experience in executing inflammatory or autoimmune disease models is a must.
          • Hands on experience in dosing rodents (PO, IP, IV, SC etc.) and tissue collection is a must.
          • Experience in primary human and mouse immune cell isolation, propagation and immune cell-based functional assays is required (e.g. T cells, B cells, myeloid cells, co-culture assays and other primary cell assays) is desirable
          • Hands on experience with a wide range of in vitro cellular and biochemical assays, including western blotting, immunoprecipitation, ELISAs, reporter assays etc. is desirable
          • Experience in flow cytometric analysis, measurement of cell surface receptors and phosphoproteins by multicolor FACS across different platforms is desirable
          • Proficiency in scientific computer programs including Microsoft Excel, GraphPad Prism, and FlowJo.
          • Must be able to design and conduct experiments based on protocols, trouble-shooting outcomes and adaptively designing follow-up experiments with minimal supervision.
          • Possess a high level of critical thinking, high energy, independence, a strong desire to learn new techniques, and the ability to work in a highly dynamic research organization.
          • The successful candidate will have clear and concise verbal and written communication skills and be able to give scientific presentations to diverse audiences.
          • Meticulous record keeping, and strong organizational skills with exceptional attention to detail are must-have requirements.Why You Should ApplyAround the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion, and integrity bring out the highest potential of each of our colleagues.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, Trenton , Senior Associate Scientist, Discovery Immunology, Healthcare , Princeton, New Jersey