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Senior Associate Scientist, Process Development - Upstream

Company: Rocket Pharmaceuticals
Location: Cranbury
Posted on: November 24, 2022

Job Description:

Work at ROCKET PHARMA and help cure rare diseases!Rocket Pharma is a fully integrated, clinical-stage company advancing gene therapies with curative potential for multiple rare childhood diseases. Rocket places enormous value on people and considers team member progress and well-being to be as important as the progress of its pipeline. We are looking for hands-on team players who enjoy collaborating with colleagues. We share a passion for seeking gene therapy cures for devastating diseases and making a difference for patients. This is an opportunity to become an integral part of a small, highly productive team and to help grow an entrepreneurial, scientifically driven organization that is increasingly recognized as a leading biotechnology innovator. In addition to a competitive compensation package featuring a generous 401K match and stock options, the position includes excellent health benefits.Process Development department is seeking a highly motivated upstream process development Senior Associate Scientist to support development of viral vector manufacturing processes.At Rocket Pharmaceuticals, Process Development (PD) department is responsible for development of high productivity, scalable and robust manufacturing processes for viral vectors using quality-by-design and phase-appropriate approaches. Process development group owns process development (first-in-human and commercial), process characterization, and tech transfer objectives for the AAV pipeline. In addition to this, PD group collaborates with Manufacturing Operations group to support clinical manufacture and process validation activities at our internal manufacturing site and at contact manufacturing sites.Reporting to Associate Director of the Upstream Process Development group, the Senior Associate Scientist will apply cell culture fundamentals and engineering principles to develop, optimize, scale-up, and transfer the upstream manufacturing processes. They will lead the execution of cell culture studies focused on stirred tank bioreactor operation including batch, fed batch and perfusion modes to support pipeline programs. Working in collaborative and matrix environment, They will innovate and establish new technologies to develop and implement process platforms for the gene therapy processes.Responsibilities:Support process development, process characterization and scale-up activities to enable high productivity, scalable and robust upstream processes for viral vector manufacturing.Lead the execution of cell culture studies in shake flask, stirred tank bioreactor and rocker-bag and high-throughput bioreactor systems.Execute laboratory studies to evaluate novel technologies to improve existing processes and establish manufacturing platforms.Support scale-down model qualification execution to enable process characterization.Support the design of experiments, data analysis and result interpretation.Interact with external CMO/CDMOs, vendors, and partners and assist in technology transfer.Collaborate effectively with process development and analytical development teams.Support laboratory investigations and equipment troubleshooting.Support authoring of laboratory procedures and process development templates.Generate high quality results and maintain high quality documentations (paper and/or e-notebooks).Requirements:BS/MS in chemical engineering, biochemical engineering, bioengineering, biochemistry, biological sciences, or relevant field of study.BS with 2+ years or MS with 0 years of hands-on experience for cell culture process development in academic settings or biotech/biopharmaceutical industry. Experience with gene therapy a plus.Conceptual understanding or hands-on experience in upstream process development for viral vectors or therapeutic proteins with suspension cell culture in shake flask, lab-scale stirred tank bioreactor, and rocker-bag system is required.Experience with high-throughput upstream process development (e.g., Ambr system) is desirable.Technical protocol and report authoring experience is desirable.Track record of planning and execution of laboratory studies to complete deliverables within specified timelines.Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner is required.A self-starter with excellent organizational skills and a solid attention to details is desired.Eager to work with highly skilled and dynamic teams in a fast-paced, entrepreneurial, and technical environment.Excellent MS Office skills with a specific focus on word, excel and power point applications to author technical reports and presentations.Experience with statistical analysis tools (e.g., JMP, Minitab) is desirable.A diverse workforce fosters innovation and strengthens Rocket's business. We ensure equal opportunity without discrimination or harassment in the workplace on the basis of gender, race, color, religion, national origin, age, physical or mental disability, pregnancy, citizenship, status as a protected veteran, marital status, sexual orientation, gender identity and expression, genetic information, or any other characteristic protected by applicable local, state, and federal laws.Full COVID-19 vaccination is required for employment at Rocket Pharmaceuticals.

Keywords: Rocket Pharmaceuticals, Trenton , Senior Associate Scientist, Process Development - Upstream, Other , Cranbury, New Jersey

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