Scientist - Protein Science

Company: Disability Solutions
Location: Princeton
Posted on: September 1, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: .BMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases. Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis. Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro. LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency. Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology. The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate. Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need. Leads Discovery and Optimization (LDO) is a diverse group of scientists and engineers providing critical lead discovery, lead evaluation, and lead profiling data to improve the understanding and increase the speed of discovery of new therapeutics. The Protein Science team in LDO plays a key role in enabling small molecule drug discovery by designing, expressing, purifying, and characterizing recombinant protein reagents that are utilized in high-throughput screens, SAR-driving and mechanistic enzyme assays, biophysical ligand-binding assays, and structural biology. We are seeking a Scientist who will help expand our impact on the structural biology portfolio. The ideal candidate will contribute to our entire structural biology pipeline from protein design to expression, purification, and characterization. This is a laboratory-based position. Key Responsibilities

• Collaborate with research program leaders in Biology, Chemistry, and colleagues in Protein Science and Structural Biology to formulate strategies for design, expression, and purification of membrane proteins to enable structure determination by cryo-EM and X-ray crystallography.
• Express recombinant membrane proteins and complexes using eukaryotic hosts
• Extract and purify functional membrane proteins and complexes
• Use analytical techniques to inform and drive construct design, protein expression, and protein purification efforts towards homogeneous membrane proteins and protein complexes suitable for structure determination by cryo-EM and X-ray crystallography.Basic Qualifications:
  • Bachelor's degree and 5+ years of academic/industry experience
  • or
  • Master's degree and 3+ years of academic/industry experience
  • or
  • Ph.D. and experience requiredPreferred Qualifications:
    • Ph.D. in Biochemistry, Cell Biology, Molecular Biology, or related field.
    • Solid understanding of molecular cloning, cell biology, and protein biochemistry
    • Experience in protein engineering and design of constructs for recombinant protein expression
    • Demonstrated knowledge and experience expressing membrane proteins using eukaryotic hosts
    • Experience with extracting and stabilizing functional proteins from membranes using selected detergents, membrane protein scaffold nanodiscs, salipros, or copolymer nanodiscs
    • Strong grasp of protein chromatography principles and experience purifying challenging proteins like GPCRs and transporters from low-abundance expression systems
    • Experience using automated chromatography workstations (e.g., AKTA Pure) and employing multi-dimensional purification strategies
    • Experience using analytical techniques to characterize membrane proteins and protein complexes, including mass photometry, light scattering (e.g., DLS, SEC-MALS), and thermal stability assays (e.g., TSA, nanoDSF)
    • A record of scientific publication employing the skills listed above
    • Experience applying laboratory automation to protein expression, purification, and/or characterization is a plus
    • Familiarity with experiment documentation using electronic lab notebook and laboratory information management system (LIMS) systems
    • Strong written and oral communication skills are required.
    • Applicants should be detail-oriented, highly organized, and able to multi-task with multiple projects. If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to . Visit to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, Trenton , Scientist - Protein Science, Other , Princeton, New Jersey