Scientist; Biochemistry, Cellular and Mechanistic Pharmacology; Lead Discovery and Optimization

Company: Disability Solutions
Location: Princeton
Posted on: September 1, 2024

Job Description:

Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us .BMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases. Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis. Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro. LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency. Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology. The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate. Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need.Lead Discovery & Optimization (LDO) is a dynamic organization that supports the entirety of drug discovery (from lead identification to clinical candidate delivery) at Bristol Myers Squibb (BMS). We employ state of the art technologies, complemented by deep subject matter expertise and broad scientific knowledge, to deliver innovative and comprehensive preclinical in vitro datasets to support our drug discovery pipeline in disease areas such as cell therapy, oncology, immunology, fibrosis, neuroscience, and cardiovascular diseases.As a Scientist within the Biochemistry, Cellular and Mechanistic Pharmacology team, this individual will be responsible for development and execution of cell-based assays designed to inform understanding of the pharmacology and mechanism of action of novel compounds in support of the broad BMS portfolio. This individual will have the opportunity to work on cross-functional drug discovery teams, closely interacting with colleagues across the Research organization. The individual will collaborate within LDO and across project teams to help shape in vitro screening strategy, identify appropriate assay platforms, and guide the mechanistic understanding of compounds toward the identification of novel therapeutic candidates. The ideal candidate will have a strong working knowledge of fundamental principles of GPCR pharmacology and cell culture, including receptor-ligand interactions and intracellular signaling transduction pathways. In addition, hands-on experience with radioligand binding assays, protein (HTRF, BRET, luminescence, ALPHA technology, ELISA, western, etc.), and nucleic acid-based (RT-qPCR) cellular assay formats is strongly desired. This is a laboratory-based position.In this role, the Scientist is expected to prepare and deliver presentations to project stakeholders. The ideal candidate will balance technical skills with critical-thinking and possess a track record of driving high quality, high-impact projects to completion. The successful candidate will be proactive, self-motivated, and team oriented. Duties:

• Design, optimize, and execute plate-based assays and mechanism of action studies
• Develop and execute high-throughput screens of large chemical libraries
• Utilize appropriate software and analytical tools to interpret and apply quality control measures to screening data
• Provide scientific and technical know-how within LDO and as a member of disease project teams
• Effectively compile and present data to project teams in both written and oral formatsBasic Qualifications:Bachelor's Degree and 5+ years of Academic / Industry experienceOrMaster's Degree and 3+ years of Academic / Industry experienceOrPhD and no years of experiencePreferred Qualifications:
  • PhD with 0 - 2 years of experience or MS with 3+ years of experience in GPCR pharmacology research; experience applying quantitative pharmacological principles is a plus
    • Demonstrated experience developing and executing receptor binding assays, kinetics, and protein/RNA quantitation
    • Demonstrated experience executing BRET assays
    • Ability to design and execute de novo cell-based assays (fluorescence, luminescence, HTRF etc.)
    • A strong understanding of cell biology, ion channels/transporters, GPCR signaling pathways, and cell culture
    • Ability to effectively analyze, interpret, and present experimental data
    • Clear and direct communication skills If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as Transforming patients' lives through science--- , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.On-site Protocol BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role: Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function. BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ eeo -accessibility to access our complete Equal Employment Opportunity statement. BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters. BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Keywords: Disability Solutions, Trenton , Scientist; Biochemistry, Cellular and Mechanistic Pharmacology; Lead Discovery and Optimization, Other , Princeton, New Jersey